Models for Antibody Behavior in Hydrophobic Interaction Chromatography and in Self-Association

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Hydrophobic Interaction Chromatography.

Most proteins and large polypeptides have hydrophobic regions at their surface. These hydrophobic "patches" are due to the presence of the side chains of hydrophobic or nonpolar amino acids such as phenylalanine, tryptophan, alanine, and methionine. These surface hydrophobic regions are interspersed between more hydrophilic or polar regions and the number, size, and distribution of them is a sp...

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ژورنال

عنوان ژورنال: Journal of Pharmaceutical Sciences

سال: 2019

ISSN: 0022-3549

DOI: 10.1016/j.xphs.2018.11.035